HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1-(4-Fluorophenyl)-4-methyl-2-phenyl-penten-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-Fluorobenzaldehyde | HCID 68023 | — |
| Reactant | Benzyl isopropyl ketone | HCID 76163 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(4-Fluorophenyl)-4-methyl-2-phenyl-penten-3-one | HCID 54434934 | — |
Reaction Steps
31 g (0.25 mol) of 4-fluorobenzaldehyde, 40.6 g (0.25 mol) of benzyl isopropyl ketone, 2.5 ml of piperidine and 1.75 ml of glacial acetic acid are boiled in a water separator for 20 hours in 200 ml of toluene. After removing the solvent, the residue is distilled through a 20 cm Vigreux column.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05032590 |
| Source dataset | uspto-grants-1991_07 |
| ORD ID | ord-7c45f599838b430a8fafa05f8c060ffc |
| Source note | uspto-grants-1991_07 |