Chlorosuccinimide → HCID 14986836, compound

Participants

Reaction Steps

6-(4-Acetylthiosemicarbazido)-1-benzyl-3-propylpyrimidine-2,4(1H,3H)-dione (7 g) was added in portions to a mixture of N-chlorosuccinimide (3 g) at room temperature and the reaction mixture was stirred 3 further hours and then there was added hexane (200 ml). Resulting crystals were collected by filtration and washed with water to give yellowish brown crystals (9.3 g), m.p. 135°-140° C. This product was used for the subsequent reaction without further purification. In a manner analogous to the above, the following compounds (Reference Examples 7 to 10) were synthesized.

Provenance & Evidence