Sodium Hydroxide → HCID 178456480, compound

HRID 1086830Notes

Reaction equation

HRID 1086830 reaction equation
C([NH:4][C:5]1[C:13]2[C:12](=[O:14])[N:11]([CH2:15][CH2:16][CH3:17])[C:10](=[O:18])[N:9]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:8]=2[NH:7][N:6]=1)(=O)C.[OH-].[Na+]>C(O)C>[NH2:4][C:5]1[C:13]2[C:12](=[O:14])[N:11]([CH2:15][CH2:16][CH3:17])[C:10](=[O:18])[N:9]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:8]=2[NH:7][N:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178456463HCID 178456463, compound

Product 1

HCID 178456480HCID 178456480, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-Acetylamino-7-benzyl-5-propylpyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (18 g) was refluxed for 5 hours in 80% ethanol (200 ml) dissolving sodium hydroxide (6 g). The reaction mixture was concentrated, and the resulting crystals were suspended in water. To the suspension was added 6N-HCl to obtain colorless crystals (11 g, 70%), m.p. 214°-215° C.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additionTo the suspension was added 6N-HCl

Sources & evidence

ORD record
ord-a0167d65b59d406585ffd0c237a669c9
Source dataset
uspto-grants-1991_07
Patent number
US05032594

Reaction notes

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