Bromine → HCID 14985977, compound

HRID 1086848Notes

Reaction equation

HRID 1086848 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:15]=[C:14]2[C:9]([CH2:10][CH2:11][CH2:12][C:13]2=[O:16])=[CH:8][CH:7]=1)(=[O:4])=[O:3].[Br:17]Br>C(Cl)Cl>[Br:17][CH:12]1[CH2:11][CH2:10][C:9]2[C:14](=[CH:15][C:6]([NH:5][S:2]([CH3:1])(=[O:4])=[O:3])=[CH:7][CH:8]=2)[C:13]1=[O:16]

Participants

4

Reactant 2

HCID 24408Bromine2×HCID 14985976HCID 14985976, compound

Product 1

HCID 14985977HCID 14985977, compoundYield 107.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of 1.4 g (0.00585 mol) of 7-methanesulfonamidotetralone in 20 mL of methylene chloride was added dropwise a solution of 0.94 g (0.0059 mol) of bromine in 5 mL of methylene chloride. The process of the reaction was followed by thin layer chromatography (fl. silica gel/CH2Cl2). A few additional drops of the bromine solution were added to completely consume the starting material. The solution was evaporated to dryness to give 2.0 g of 2-bromo-7-methanesulfonamido-1-tetralone, mp 87°-92° C.

Workup

  1. customto completely consume the starting material
  2. customThe solution was evaporated to dryness

Sources & evidence

ORD record
ord-77a93f09e7144b5da3002d430b20f05c
Source dataset
uspto-grants-1991_07
Patent number
US05032598

Reaction notes

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