Morpholine → N-(Benzyloxyacetyl)morpholine

HRID 1086865Notes

Reaction equation

HRID 1086865 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH2:7]([O:14][CH2:15][C:16](O)=[O:17])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[CH2:7]([O:14][CH2:15][C:16]([N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1)=[O:17])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 290301(Benzyloxy)acetic acid

Product 1

HCID 19761610N-(Benzyloxyacetyl)morpholineYield 90%

Procedure

Using the mixed anhydride procedure described in Example 2, morpholine was coupled to benzyloxyacetic acid to give the desired product in 90% yield.

Sources & evidence

ORD record
ord-4f467f90be6c458a8965906cf39f951a
Source dataset
uspto-grants-1991_07
Patent number
US05032577

Reaction notes

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