Water → HCID 19818669, compound

HRID 1086873Notes

Reaction equation

HRID 1086873 reaction equation
[Br:1]Br.[C:3]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][N:8]=1)(=[O:6])[CH2:4][CH3:5].O>C(Cl)(Cl)Cl>[Br:1][CH:4]([CH3:5])[C:3]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:14])[F:15])=[CH:9][N:8]=1)=[O:6]

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 19818686HCID 19818686, compound

Product 1

HCID 19818669HCID 19818669, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

Bromine (0.52 ml.) in chloroform (50 ml.) was added to solution of 2-propionyl 5-trifluoromethylpyridine (2.03 g.) in chloroform (20 ml.) over 1 hour under photoflood illumination. After addition was complete the reaction was stirred for 16 hours at room temperature. The reaction was then poured into water, and the organic phase was separated, washed with water, dried over magnesium sulphate and concentrated to dryness to give 2-(2-bromopropionyl)-5-trifluoromethylpyridine as an oil which was used without further purification.

Workup

  1. additionAfter addition
  2. customthe organic phase was separated
  3. washwashed with water
  4. dry with materialdried over magnesium sulphate
  5. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-6c502f0d76dc4380a6de934c674b9b3c
Source dataset
uspto-grants-1991_07
Patent number
US05032607

Reaction notes

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