Sodium Hydroxide → HCID 15067926, compound

HRID 1086949Notes

Reaction equation

HRID 1086949 reaction equation
[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[C:5]([C:13]([O:15]C)=[O:14])[C:4]=1[C:17]1[C:22]([C:23]([O:25]C)=[O:24])=[CH:21][C:20]2[O:27][CH2:28][O:29][C:19]=2[C:18]=1[O:30][CH3:31].[OH-].[Na+]>CO>[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[C:5]([C:13]([OH:15])=[O:14])[C:4]=1[C:17]1[C:22]([C:23]([OH:25])=[O:24])=[CH:21][C:20]2[O:27][CH2:28][O:29][C:19]=2[C:18]=1[O:30][CH3:31]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14372323HCID 14372323, compound

Product 1

HCID 15067926HCID 15067926, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 20 ml of methanol was dissolved 1.75 g of dimethyl 2,2',3,4-tetramethoxy-3',4'-methylenedioxy-1,1'-biphenyl-6,6'-dicarboxylate obtained in Example 2, and 10 ml of a 10% aqueous solution of sodium hydroxide was added to the solution and the mixture was heated and refluxed for 16 hours. After termination of the reaction, the reaction mixture was cooled and the precipitated crystals were recovered by filtration and recrystallized from methanol to obtain 1.3 g of 2,2',3,4- tetramethoxy-3',4'-methylenedioxy-1,1'-biphenyl-6,6'-dicarboxylic acid (the yield was 81%)

Workup

  1. additionwas added to the solution
  2. temperaturethe mixture was heated
  3. temperaturerefluxed for 16 hours
  4. customAfter termination of the reaction
  5. temperaturethe reaction mixture was cooled
  6. filtrationthe precipitated crystals were recovered by filtration
  7. customrecrystallized from methanol

Sources & evidence

ORD record
ord-37597c4b14614abcaba18de81fe9616c
Source dataset
uspto-grants-1991_07
Patent number
US05032685

Reaction notes

Loading…