7-fluoro-6-isocyanato-4-propargyl-2H-1,4-benzoxazin-3(4H)-one → 5,8-dihydro-2-(6-fluoro-3-propargyl-2-benzothiazolon-5-yl)-1H-[1,2,4]triazolo-[1,2-a]pyridazine-1-thion-3(2H)-one

Participants

Reaction Steps

In place of 6-fluoro-5-isocyanato-3-propargyl-2-benzothiazolone in the foregoing Example 1, use was made of 6-fluoro-5-isothiocyanato-3-propargyl-2-benzothiazolone and 7-fluoro-6-isocyanato-4-propargyl-4H-1,4-benzoxazin-3-one so as to obtain 5,8-dihydro-2-(6-fluoro-3-propargyl-2-benzothiazolon-5-yl)-1H-[1,2,4]triazolo-[1,2-a]pyridazine-1-thion-3(2H)-one and 5,8-dihydro-2-(7-fluoro-4-propargyl-4H-1,4-benzoxazin-3(4H)-on-6-yl)-1H-[1,2,4]triazolo-[1,2-a]pyridazine-1,3(2H)-dione, respectively.

Provenance & Evidence