Formaldehyde → HCID 86744920, compound

HRID 1086983Notes

Reaction equation

HRID 1086983 reaction equation
[CH2:1]([C:8]1[CH:16]=[C:12]([C:13]([OH:15])=[O:14])[C:11]([OH:17])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH3:19].[CH2:26]=[O:27].S(=O)(=O)(O)O>C(O)(=O)C>[CH2:1]([C:8]1[CH:16]=[C:12]([C:13]([OH:15])=[O:14])[C:11]([OH:17])=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[CH2:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH:26]=[O:27])[CH3:19]

Participants

6

Reactant 4

HCID 712FormaldehydeHCID 1118Sulfuric AcidHCID 7500EthylbenzeneHCID 222562635-Benzyl-2-hydroxybenzoic acid

Product 1

HCID 86744920HCID 86744920, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a mixture of 22.8 parts of 5-benzylsalicylic acid, 21.2 parts of ethylbenzene, 3.8 parts of 87% paraformaldehyde and 25 parts of acetic acid was added 1.0 part of 95% sulfuric acid (catalyst). After being heated under reflux for 4 hours, the reaction mixture was washed with water, and unreacted ethylbenzene and water were removed by vacuum distillation to give 33 parts of 5-benzylsalicylic acid-ethylbenzene-formaldehyde co-condensation product. 10 parts of the co-condensation product was converted into its zinc salt in a similar manner as in Synthesis Example 1. There was obtained 11 parts of zinc salt of 5-benzylsalicylic acid-ethylbenzene-formaldehyde co-condensation product.

Workup

  1. temperatureAfter being heated
  2. temperatureunder reflux for 4 hours
  3. washthe reaction mixture was washed with water, and unreacted ethylbenzene and water
  4. customwere removed by vacuum distillation

Sources & evidence

ORD record
ord-bef426fe5d8948afb15f69a690ba5142
Source dataset
uspto-grants-1991_07
Patent number
US05034370

Reaction notes

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