Formamide → 3H,4H-pyrido(3,4-d)pyrimidin-4-one

HRID 1086997Notes

Reaction equation

HRID 1086997 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]([OH:10])=O.[CH:11]([NH2:13])=O>O>[N:1]1[C:2]2[CH:3]=[N:4][CH:5]=[CH:6][C:7]=2[C:8](=[O:10])[NH:13][CH:11]=1

Participants

4

Reactant 2

HCID 713FormamideHCID 4595313-Aminoisonicotinic acid

Product 1

HCID 1355671063H,4H-pyrido(3,4-d)pyrimidin-4-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
170 °C

Procedure

A mixture of 4 g of 3-amino-pyridine-4-carboxylic acid in 15 mL of formamide was heated in an oil bath to 160-180° C. After one hour the mixture was allowed to cool. Then, the mixture was slurried in 25 mL of water and filtered. The product was recrystallized from water. Yield 3.3 g. M.P. 317° C. (with sublimation).

Workup

  1. temperatureto cool
  2. filtrationfiltered
  3. customThe product was recrystallized from water

Sources & evidence

ORD record
ord-5f5076d34e134f82864ca2d3d7791342
Source dataset
uspto-grants-1991_07
Patent number
US05034393

Reaction notes

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