反应详情

A mixture of 3 g (12.6 mmoles) 6-chloroacetyl-3methyl-3,4-dihydro-1H-quinazolin-2-one, 2.4 g 4-(phenoxymethyl)piperidine, 1.7 g sodium carbonate, 70 ml ethanol and 15 ml water is heated under reflux for 2 h. The mixture is cooled, 6 g potassium borohydride are added slowly, and the mixture is allowed to return to ambient temperature while stirring. 125 ml water are added, the mixture is stirred for 1 h, then the solid is filtered off, washed with water, and recrystallized from ethanol. 5.1 g of compound are finally isolated.

1. temperatureis heated
2. temperatureunder reflux for 2 h
3. temperatureThe mixture is cooled
4. customto return to ambient temperature
5. stirringthe mixture is stirred for 1 h
6. filtrationthe solid is filtered off
7. washwashed with water
8. customrecrystallized from ethanol