反应详情

A solution of 3-fluoro-4-nitropyridine-1-oxide (5.6 g) and indan-1-amine (6 g) in 100 ml ethanol was stirred at reflux for one hour and thereafter cooled and concentrated to 12 g of solid. This solid was purified by flash chromatography (silica, 10% ethyl acetate in dichloromethane) to give 9.2 g solid, m.p. 137°-138°. An analytical sample was obtained by recrystallizing 2.7 g from ethanol to give 2.5 g crystals, m.p. 141°-142°.

1. temperatureat reflux for one hour
2. temperaturecooled
3. concentrationconcentrated to 12 g of solid
4. customThis solid was purified by flash chromatography (silica, 10% ethyl acetate in dichloromethane)