HCID 20079498, compound → HCID 15053103, compound

Participants

Reaction Steps

A mixture of N-(4-nitro-3-pyridinyl)-1H-indol-5-amine, N5 -oxide (7.8 g) in 500 ml ethanol containing platinum oxide (1.25 g) was hydrogenated at 50 psi for six hours and thereafter filtered and concentrated. The product was purified by flash chromatography (silica, 20% methanol in dichloromethane) to give 6 g solid, m.p. 83°-90°. Three grams were distilled twice via Kugelrohr (240°-250° @ 0.01 mm Hg) to give 2.4 g solid, 138°-140°.

Provenance & Evidence