HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → ethyl (R/S)-2-(3-acetoxy-2-oxo-1-pyrrolidinyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | ethyl (R/S)-2-(3-hydroxy-2oxo-1-pyrrolidinyl)acetate | HCID 13385945 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | ethyl (R/S)-2-(3-acetoxy-2-oxo-1-pyrrolidinyl)acetate | HCID 131713898 | — |
Reaction Steps
1.70 g of ethyl (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetate are boiled at reflux for 2.5 hours while stirring in 30 ml of methylene chloride and 0.53 ml of acetyl chloride. The mixture is then evaporated. The residue is distilled in a bulb-tube. There is obtained ethyl (R/S)-2-(3-acetoxy-2-oxo-1-pyrrolidinyl)acetate of boiling point 225°/0.01 mmHg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05034402 |
| Source dataset | uspto-grants-1991_07 |
| ORD ID | ord-db7b00240d5443548e4cae991249985b |
| Source note | uspto-grants-1991_07 |