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HRID1087087

反应详情

EQUATION

反应方程式

HRID 1087087 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)n1ccnc1
HCID17174

1H-Imidazole, 1-acetyl-

C5H6N2O

结构：C[C@@H]1CCC[C@H](C)N1CCNC(=O)CN1CCC(O)C1=O
HCID3069833

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)OC1CCN(CC(=O)NCCN2[C@H](C)CCC[C@@H]2C)C1=O
HCID53715870

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

0.594 g of (R/S)-cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide is boiled at reflux for 4 hours with 0.222 g of N-acetylimidazole in 10 ml of toluene. The mixture is chromatographed over 21 g of aluminum oxide (activity grade III, neutral). The (R/S)-cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-(3-acetoxy-2-oxo-1-pyrrolidinyl)acetamide which is eluted with methylene chloride has a melting point of 120°-121° after crystallization from diethyl ether.

WORKUP

后处理

  1. customThe mixture is chromatographed over 21 g of aluminum oxide (activity grade III, neutral)
  2. washThe (R/S)-cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-(3-acetoxy-2-oxo-1-pyrrolidinyl)acetamide which is eluted with methylene chloride
  3. customafter crystallization from diethyl ether