Glycine → HCID 14774522, compound

Participants

Reaction Steps

2.0 g (0.027 mol) of glycine are dissolved in 7 ml of 4 N NaOH and 2,2-dichloro-1-methylcyclopropanecarbonyl chloride and 6.5 ml of 4 N NaOH solution are added in portions at 5 to 10° C., while cooling with ice, the pH being kept>8. The mixture is subsequently stirred for 30 minutes, the aqueous phase is extracted twice with ether and acidified to about pH 2 with 1 N HCl and the precipitate formed is filtered off with suction. After drying, 4.5 g (74% of theory) of N-(2,2-dichloro-1-methylcyclopropanoyl)-glycine of melting point 139-140° C. are obtained.

Provenance & Evidence