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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1087103Generated: October 30, 2026

5-(Aminomethyl)-2-chloropyridine → 1-(6-Chloro-3-pyridylmethyl)-3-methyl2-nitroguanidine

https://huagongshe.com/reaction/1087103

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Aminomethyl)-2-chloropyridineHCID 7020927—
Reactant1,2-Dimethyl-3-nitroisothioureaHCID 136227017—
SolventEthanolHCID 702—
Product1-(6-Chloro-3-pyridylmethyl)-3-methyl2-nitroguanidineHCID 13621819634%

Reaction Steps

A mixture of 0.45g of 1,2-dimethyl-3-nitroisothiourea, 0.43g of 5-(aminomethyl)-2-chloropyridine and 25ml of ethanol was refluxed for 6 hours and concentrated. The residue was purified by a column chromatography [developing solvent: chloroform-ethanol (5:1)] to afford 0.25g of 1-(6-chloro-3-pyridylmethyl)-3-methyl-2-nitroguanidine (Compound No. 5).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05034404
Source datasetuspto-grants-1991_07
ORD IDord-5a29a5580a9b4b6585d984440e5467d9
Source noteuspto-grants-1991_07