Acetonitrile → HCID 178485033, compound

Participants

Reaction Steps

A mixture of 1.03g of 1-(6-chloro-3-pyridyl)-3methylthiourea, 0.32g of cyanamide, 1.58g of dicyclohexylcarbodiimide, 3 drops of ethyl diisopropylamine and 10ml of acetonitrile was stirred for 34 hours at room temperature and filtered to collect an insoluble substance. The insoluble substance was recrystallized from a mixed solvent cf acetonitrile and methanol, and then from acetonitrile to obtain 0.31g of 1-(6-chloro-pyridyl)-2-cyano-3-methylguanidine (Compound No. 24).

Provenance & Evidence