反应详情

温度

60 °C

A mixture of 0.39g of 5-(aminomethyl)-2-bromothiazole, 0.30g of 1,2-dimethyl-3-nitroisothiourea, 0.58g of cuprous bromide, 0.55g of anhydrous potassium carbonate and 4ml of dry acetonitrile was stirred in an oil bath of 60° C. for 45 minutes. The reaction mixture was purified by a column chromatography [developing solvent: dichloromethane-methanol (10:1)] to obtain 1-(2-bromo-5-thiazolylmethyl)-3-methyl-2-nitroguanidine (Compound No. 39), as white solid.

1. customThe reaction mixture was purified by a column chromatography [developing solvent: dichloromethane-methanol (10:1)]