Potassium Carbonate → 1-(2-Bromo-5-thiazolylmethyl)-3-methyl-2-nitroguanidine

HRID 1087110Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1087110
[NH2:1][CH2:2][C:3]1[S:7][C:6]([Br:8])=[N:5][CH:4]=1.[CH3:9][NH:10][C:11](=[N:14][N+:15]([O-:17])=[O:16])SC.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Br:8][C:6]1[S:7][C:3]([CH2:2][NH:1][C:11]([NH:10][CH3:9])=[N:14][N+:15]([O-:17])=[O:16])=[CH:4][N:5]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 15171120(2-Bromothiazol-5-yl)methanamineHCID 1362270171,2-Dimethyl-3-nitroisothiourea

Produkt 1

HCID 1363411821-(2-Bromo-5-thiazolylmethyl)-3-methyl-2-nitroguanidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 0.39g of 5-(aminomethyl)-2-bromothiazole, 0.30g of 1,2-dimethyl-3-nitroisothiourea, 0.58g of cuprous bromide, 0.55g of anhydrous potassium carbonate and 4ml of dry acetonitrile was stirred in an oil bath of 60° C. for 45 minutes. The reaction mixture was purified by a column chromatography [developing solvent: dichloromethane-methanol (10:1)] to obtain 1-(2-bromo-5-thiazolylmethyl)-3-methyl-2-nitroguanidine (Compound No. 39), as white solid.

Aufarbeitung

  1. customThe reaction mixture was purified by a column chromatography [developing solvent: dichloromethane-methanol (10:1)]

Quellen und Nachweise

ORD-Eintrag
ord-8348dbb7fe1c4237a65c3c30e92a91e1
Quelldatensatz
uspto-grants-1991_07
Patentnummer
US05034404

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