Acetyl chloride → HCID 15158833, compound

Participants

Reaction Steps

To a solution of sodium hydroxide (0.9 g in 25 ml dioxan) was added 4-[3-[ethyl[3-[(4-hydroxyphenyl)thio]propyl]amino]-2-hydroxypropoxy]-benzonitrile (3.4 g, 8.8 mmol) and tetrabutylammonium hydrogen sulphate. To the solution was added dropwise acetylchloride (0.78 g, 10 mmol) dissolved in dioxan (10 ml). The solution was stirred at room temperature for 2 h. After filtration and evaporation the residue was dissolved in methylene chloride, treated with charcoal and filtered through Celite. The solvent was evaporated. The yield of the title compound was 3.8 g.

Provenance & Evidence