3-Nitrobenzaldehyde → HCID 15632018, compound

Participants

Reaction Steps

3.36 Grams of 1-[2(E)-acetoacetocymethylvinyl]-(4-(2-tetrahydropyranyloxy)benzene, 1.5 g of 3-nitrobenzaldehyde and 1.2 g of methyl 3-aminocrotonate were added to 20 ml of isopropanol, and the mixture was refluxed for 8 hours. The reaction mixture was concentrated and the residue was purified by means of a silica gel column chromatography (eluent: chloroform) to yield 1.2 g of methyl 3-(4-tetrahydropyranyloxyphenyl)-2(E)-propenyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate.

Provenance & Evidence