Sodium Methoxide → HCID 14726452, compound

Participants

Reaction Steps

4.2 g (0.011 mol) of 5-chloro-2-methyl-4-((2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)amino)-3(2H)-pyridazinone are heated in methanol, in which 0.010 mol of sodium methylate is dissolved, under reflux for 50 hours and then concentrated in vacuo. The residue is taken up in water, when 1.6 g of 5-methoxy-2-methyl-4-((2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)amino)-3(2H)-pyridazinone (38.9% of theory) precipitate out. The solid is filtered off with suction, dried, dissolved in acetone and converted by addition of fumaric acid at the reflux temperature into 1.50 g (24.5% of theory) of fumarate, m.p. 144°-148° C.; C 54.0%, H 6.1%, N 12.5%, O 27.4%, UV in 0.1N H

Provenance & Evidence