Water → 3-(2,4-Difluorophenylthio)-4-nitrobenzoic acid

HRID 1087173Notes

Reaction equation

HRID 1087173 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9][C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][C:17]=1[N+:18]([O-:20])=[O:19])[C:13]#N.S(=O)(=O)(O)[OH:22].[OH2:26]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9][C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][C:17]=1[N+:18]([O-:20])=[O:19])[C:13]([OH:22])=[O:26]

Participants

4

Reactant 3

HCID 962Water2×HCID 1118Sulfuric AcidHCID 102663153-(2,4-Difluorophenylthio)-4-nitrobenzonitrile

Product 1

HCID 100867683-(2,4-Difluorophenylthio)-4-nitrobenzoic acid

Conditions

Temperature
175 °C

Procedure

A mixture of 3-(2,4-difluorophenylthio)-4-nitrobenzonitrile (3.6 g), sulfuric acid (3 ml) and water (3 ml) as stirred at 175° C. for 15 minutes. Water as added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was dried over magnesium sulfate and evaporated to give crystals of 3-(2,4-difluorophenylthio)-4-nitrobenzoic acid (3.6 g).

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe extract was dried over magnesium sulfate
  3. customevaporated

Sources & evidence

ORD record
ord-2c4e7f753d9742e9a38620e02798542d
Source dataset
uspto-grants-1991_07
Patent number
US05034417

Reaction notes

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