Phosphorus pentachloride → 3-(2,4-Difluorophenylthio)-4-nitrobenzoyl chloride

HRID 1087176Notes

Reaction equation

HRID 1087176 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][C:18]=1[N+:19]([O-:21])=[O:20])[C:13](O)=[O:14].P(Cl)(Cl)(Cl)(Cl)[Cl:23]>C1C=CC=CC=1>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][C:18]=1[N+:19]([O-:21])=[O:20])[C:13]([Cl:23])=[O:14]

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 100867683-(2,4-Difluorophenylthio)-4-nitrobenzoic acid

Product 1

HCID 103592393-(2,4-Difluorophenylthio)-4-nitrobenzoyl chlorideYield 113.3%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 3-(2,4-difluorophenylthio)-4-nitrobenzoic acid (1 g) and phosphorus pentachloride (0.7 g) in benzene (10 ml) was stirred at room temperature for 30 minutes. The mixture was concentrated under reduced pressure to give a powder of 3-(2,4-difluorophenylthio)-4-nitrobenzoyl chloride (1.2 g).

Workup

  1. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-7cdfacbfe9bc4c31985c6b2585c95e8e
Source dataset
uspto-grants-1991_07
Patent number
US05034417

Reaction notes

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