HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4'-Nitro-3'-(2-pyridylthio)acetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-(3-Chloro-4-nitrophenyl)ethanone | HCID 10442755 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | HCID 178418616 | HCID 178418616 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4'-Nitro-3'-(2-pyridylthio)acetophenone | HCID 10084712 | 53.4% |
Reaction Steps
A mixture of 2-mercaptopyridine (1.7 g), potassium t-butoxide (1.7 g) and N,N-dimethylformamide (3 ml) in toluene (15 ml) was stirred at room temperature for 30 minutes. To the mixture was added 4'-nitro-3'-chloroacetophenone (1.5 g) and the resulting mixture was stirred overnight. Water was added and the insoluble material was filtered, washed with toluene and dried to give crystals of 4'-nitro-3'-(2-pyridylthio)acetophenone (1.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05034417 |
| Source dataset | uspto-grants-1991_07 |
| ORD ID | ord-47589cb8713c42af987a7ae953e2e37f |
| Source note | uspto-grants-1991_07 |