HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1087185Generated: October 31, 2026
p-Chlorothiophenol → 3'-(4-Chlorophenylthio)-4'-nitroacetophenone
https://huagongshe.com/reaction/1087185
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Chlorothiophenol | HCID 7815 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(3-Chloro-4-nitrophenyl)ethanone | HCID 10442755 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3'-(4-Chlorophenylthio)-4'-nitroacetophenone | HCID 10380526 | 82.1% |
Reaction Steps
A mixture of 3'-chloro-4'-nitroacetophenone (1.5 g), 4-chlorothiophenol (1.63 g) and potassium carbonate (1.56 g) in toluene (15 ml) was stirred at 70° C. for 5 hours. Ethyl acetate and water were added, and the organic layer was separated, washed with water, dried and evaporated to dryness. The residue was washed with toluene to give yellow crystals of 3'-(4-chlorophenylthio)-4'-nitroacetophenone (1.9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05034417 |
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| Source dataset | uspto-grants-1991_07 |
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| ORD ID | ord-498c9783497a48b38347c9b20a02403c |
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| Source note | uspto-grants-1991_07 |
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