HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 2-Chloro-5-(2,4-difluorophenylthio)-4-nitrobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 2,5-Dichloro-4-nitrobenzonitrile | HCID 19817734 | — |
| Reactant | Potassium 2,4-difluorothiophenoxide | HCID 23700122 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Chloro-5-(2,4-difluorophenylthio)-4-nitrobenzonitrile | HCID 19817701 | 45.2% |
Reaction Steps
A mixture of 2,5-dichloro-4-nitrobenzonitrile (2.5 g) and potassium 2,4-difluorothiophenoxide (2.54 g) in toluene was stirred overnight. Ethyl acetate was added and the resulting mixture was washed with water, dried and evaporated. The residue was filtered and washed with toluene to give pale brown crystals of 2-chloro-5-(2,4-difluorophenylthio)-4-nitrobenzonitrile (1.7 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05034417 |
| Source dataset | uspto-grants-1991_07 |
| ORD ID | ord-6d73aab75ba54c018334c300b3d59aa7 |
| Source note | uspto-grants-1991_07 |