反应详情

A mixture of 4'-acetyl-2'-(2,4-difluorophenylthio)methanesulfonanilide methanesulfonanilide (1.16 g), semicarbazide hydrochloride (0.4 g), and pyridine (0.29 ml) in ethanol (15 ml) was stirred and refluxed for 2 hours. The mixture was concentrated under reduced pressure. The residue was triturated with water, filtered, washed with water, and recrystallized from methanol to give a powder of 3'-(2,4-difluorophenylthio)-4'-methanesulfonamidoacetophenone semicarbazone (0.92 g).

1. temperaturerefluxed for 2 hours
2. concentrationThe mixture was concentrated under reduced pressure
3. customThe residue was triturated with water
4. filtrationfiltered
5. washwashed with water
6. customrecrystallized from methanol