HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl Peroxide → 4'-Bromoacetyl-2'(2,4-difluorophenylthio)methanesulfonanilide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Methanesulfonamide, N-[4-acetyl-2-[(2,4-difluorophenyl)thio]phenyl]- | HCID 10450972 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4'-Bromoacetyl-2'(2,4-difluorophenylthio)methanesulfonanilide | HCID 14973032 | — |
Reaction Steps
A solution of bromine (0.81 g) in chloroform (5 ml) was added dropwise to a stirred solution of 4'-acetyl2'-(2,4-difluorophenylthio)methanesulfonanilide (1.8 g) and benzoyl peroxide (8 mg) in chloroform (20 ml). After stirring for 1 hour at room temperature, the mixture was washed with water and an aqueous solution of sodium bisulfite successively. The organic layer was dried and concentrated to give 4'-bromoacetyl-2'(2,4-difluorophenylthio)methanesulfonanilide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05034417 |
| Source dataset | uspto-grants-1991_07 |
| ORD ID | ord-6ff590fc5ce44092b33c4876c6aeb557 |
| Source note | uspto-grants-1991_07 |