Methanesulfonyl chloride → HCID 10383478, compound

Participants

Reaction Steps

A mixture of 4'-amino-3'-[N-methyl-N-(2,4-difluorophenyl)aminoacetophenone (1.2 g) and methanesulfonyl chloride (0.6 g) in pyridine was stirred at room temperature for 7 hours. The mixture was evaporated and the residue was stirred with 5% sodium hydroxide (30 ml) overnight. The mixture was washed with toluene, and the aqueous layer was acidified with hydrochloric acid and extracted with ethyl acetate. The extract was concentrated and the residue was recrystallized from ethanol to give pale brown prisms of 4'-acetyl2'-[N-methyl-N-(2,4-difluorophenyl)amino]methanesulfonanilide (0.49 g).

Provenance & Evidence