2,4-Difluorobenzoyl chloride → HCID 10451647, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4'-acetyl-2'-aminomethanesulfonanilide (1.6 g) and 2,4-difluorobenzoyl chloride (1.5 g) in pyridine (15 ml) was stirred at 0° C. for 3 hours. The mixture was evaporated and the residue was stirred with 5% sodium hydroxide (40 ml) for 1 hour at room temperature. The mixture was washed with toluene, and the aqueous layer was acidified with hydrochloric acid. The precipitates obtained were recrystallized from a mixture of acetone and ethyl acetate (1:1) to give pale brown needles of N-(5-acetyl-2-methanesulfonamidophenyl)-2,4-difluorobenzamide (1.3 g).

Provenance & Evidence