反应详情

A mixture of N-ethyl-4-amino-3-(2,4-difluorophenylthio)benzamide (0.84 g) and methanesulfonyl chloride (0.57 g) in pyridine (5 ml) was stirred at room temperature overnight. The reaction mixture was concentrated. The residue was dissolved in ethyl acetate, washed with dilute hydrochloric acid, dried and evaporated. The residue obtained was dissolved in methanol and treated with potassium hydroxide (0.4 g). The solution was concentrated and the residue was dissolved in water. The aqueous solution was acidified with dilute hydrochloric acid and extracted with chloroform. The extract was washed with water, dried, and evaporated. The residual solid was recrystallized from ethanol to give N-ethyl-3-(2,4-difluorophenylthio)-4-(methanesulfonamido)benzamide (0.67 g).

1. concentrationThe reaction mixture was concentrated
2. dissolutionThe residue was dissolved in ethyl acetate
3. washwashed with dilute hydrochloric acid
4. customdried
5. customevaporated
6. customThe residue obtained
7. concentrationThe solution was concentrated
8. dissolutionthe residue was dissolved in water
9. extractionextracted with chloroform
10. washThe extract was washed with water
11. customdried
12. customevaporated
13. customThe residual solid was recrystallized from ethanol