Acetic Acid → HCID 19817708, compound

Participants

Reaction Steps

Sodium borohydride (1.49 g) was added portionwise to a stirred mixture of 2'-(2,4-difluorobenzoyl)-4'-nitromethanesulfonanilide (5.6 g) in tetrahydrofuran (50 ml). The mixture was stirred at room temperature for 4 hours, treated with acetic acid (5 ml) and water (20 ml), had concentrated to dryness. The residue was dissolved in ethyl acetate and washed with water. The organic layer was dried and evaporated to give a powder of 2'-(2,4-difluoro-α-hydroxybenzyl)-4'-nitromethanesulfonanilide (5.3 g).

Provenance & Evidence