Cephalexin → Cephalexin Monohydrate

Participants

Reaction Conditions

Reaction Steps

IPA (16 liters) was added to the aqueous phase and the pH was slowly lowered to 7.7 by acid addition [step (e)]. The system was seeded with cephalexin and, after crystallization began, the pH was lowered in 0.1 pH unit increments by acid addition to pH 7.0 [step (f)], and finally to pH 5.0 [step (h)]. The crystal slurry was chilled to 1° C. for 1 hour [step (g)], then centrifuged to obtain a cephalexin monohydrate product [step (h)].

Provenance & Evidence