Methanesulfonic Acid → 7-Amino-3-methoxymethyl-3-cephem-4-carboxylic acid

Participants

Reaction Steps

To 10 ml of dichloromethane were added 1.41 g of 7-ACA, 5.1 ml of methanesulfonic acid and 1.07 ml of trimethyl borate. The reaction was conducted at 0° C. for 9 hours. After completion of the reaction, substantially the same procedure as in Example 1 was repeated, to thereby obtain the desired product, namely 7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid. The amount of the desired product was 0.70 g. The yield of the desired product was 55%.

Provenance & Evidence