Sulfuric Acid → 7-Amino-3-methoxymethyl-3-cephem-4-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To 10 ml of methyl acetate were added 1.41 g of 7-ACA, 3.0 g of zinc chloride, 0.29 ml of concentrated sulfuric acid and 3.13 ml of trimethyl borate. The mixture was heated at 30° C. for 6 hours to advance a reaction. After completion of the reaction, substantially the same procedure as in Example 1 was repeated, to thereby obtain the desired product, namely 7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid. The amount of the desired product was 0.86 g. The yield of the desired product was 69%.

Provenance & Evidence