Methanesulfonic Acid → 7-Amino-3-methoxymethyl-3-cephem-4-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To 10 ml of sulfolane were added 1.41 g of 7-ACA, 2.4 ml of boron trifluoride ethyl ether, 0.34 ml of methanesulfonic acid and 3.13 ml of trimethyl borate. The mixture was heated at 30° C. for 5 hours to advance a reaction. After completion of the reaction, substantially the same procedure as in Example 1 was repeated, to thereby obtain the desired product, namely 7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid. The amount of the desired product was 0.49 g. The yield of the desired product was 39%.

Provenance & Evidence