Boron trifluoride etherate → 7-Amino-3-methoxymethyl-3-cephem-4-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To 10 ml of sulfolane were added 1.41 g of 7-ACA, 6.3 ml of boron trifluoride ethyl ether and 2.30 ml of methanol. The mixture was heated at 50° C. for 3.5 hours to advance a reaction. After completion of the reaction, substantially the same procedure as in Example 1 was repeated, to thereby obtain the desired product, namely 7-amino-3-methoxy methyl-3-cephem-4-carboxylic acid. The amount of the desired product was 0.87 g. The yield of the desired product was 69%.

Provenance & Evidence