Sulfuric Acid → 7-Amino-3-methoxymethyl-3-cephem-4-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To 10 ml of sulfolane were added 1.41 g of 7-ACA, 0.3 ml of concentrated sulfuric acid, 1.96 g of ferric chloride and 1.15 ml of methyl orthoformate. The mixture was heated at 30° C. for 5 hours to advance a reaction. After completion of the reaction, substantially the same procedure as in Example 1 was repeated, to thereby obtain a desired product, namely 7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid. The amount of the desired product was 0.75 g. The yield of the desired product was 59%.

Provenance & Evidence