反应详情

温度

0 °C

To the stirred acetone solution of metoprolol base (19.3 mol), acetone (30 l) and sorbic acid (2.12 kg, 18.9 mol) were added at room temperature. The mixture was heated to reflux and the hot solution was filtered. The filtrate was allowed to cool slowly to 0° C. The crystals were centrifugated off, washed with cold acetone (10 l) and dried for three days in vacuo at room temperature to yield 5.95 kg of crystalline (S)-metoprolol. (81% from (4)).

1. temperatureThe mixture was heated
2. temperatureto reflux
3. filtrationthe hot solution was filtered
4. washwashed with cold acetone (10 l)
5. customdried for three days in vacuo at room temperature