Chloroform → HCID 178437194, compound

HRID 1087290Notes

Reaction equation

HRID 1087290 reaction equation
[ClH:1].Cl.[NH2:3][CH:4]([CH:7]([C:9]1[N:10]=[CH:11][NH:12][CH:13]=1)[CH3:8])CO.[CH:14]([Cl:17])(Cl)[Cl:15]>C1S(=O)(=O)CCC1.S(Cl)(Cl)=O>[ClH:15].[ClH:1].[NH2:3][CH:4]([CH:7]([C:9]1[N:10]=[CH:11][NH:12][CH:13]=1)[CH3:8])[CH2:14][Cl:17]

Participants

5

Reactant 2

HCID 6212ChloroformHCID 178437196HCID 178437196, compound

Product 1

HCID 178437194HCID 178437194, compound

Reagents, catalysts & solvents 2

HCID 24386Thionyl ChlorideSolventHCID 31347SulfolaneSolvent

Procedure

3 g (13.2 mmol) 2-amino-3-(1H-imidazol-4-yl)butanol dihydrochloride are solved in a mixture of 25 ml tetramethylenesulfone and 10 ml thionyl chloride and stirred 12 hours at room temperature. Dropwise addition of 200 ml chloroform affords 2-amino-1-chloro-3-(1H-imidazol-4-yl)butane dihydrochloride. Yield: 2.87 g (88.2%) of a hygroscopic precipitate.

Sources & evidence

ORD record
ord-73fff42a7bde4c95bc21513e9b0d5852
Source dataset
uspto-grants-1991_07
Patent number
US05034539

Reaction notes

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