Methanol → HCID 178418785, compound

HRID 1087292Notes

Reaction equation

HRID 1087292 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]([OH:8])=[O:7])[N:3]=[CH:2]1.[CH3:9]O>>[NH:1]1[CH:5]=[C:4]([C:6]([O:8][CH3:9])=[O:7])[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 887MethanolHCID 178524800HCID 178524800, compound

Product 1

HCID 178418785HCID 178418785, compound

Procedure

112.09 g (1 mol) (1H-imidazol-4-yl)carboxylic acid are added to 1.3 l methanol. Dry HCl-gas is bubbled through the mixture which is heated under reflux for 4 hours. Cooling to room temperature and evaporation to 300 ml afford 98 g of the title compound as white crystals. Repeated evaporation leads to 46.5 g additional material (total: 144.5 g, 88.9%). An analytical sample is recrystallized from methanol, melting point: 173°-174° C. (ref.1) mp: 156° C.).

Workup

  1. customDry HCl-gas is bubbled through the mixture which
  2. temperatureis heated
  3. temperatureunder reflux for 4 hours
  4. customevaporation to 300 ml

Sources & evidence

ORD record
ord-9ad876e2765e4df0adbc25b62eb7bfe1
Source dataset
uspto-grants-1991_07
Patent number
US05034539

Reaction notes

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