反应详情

1-(n-octylsulfonylamino)-8-aminoanthraquinone (0.25g), 1-ethylhexanoyl chloride (0.5g) and nitrobenzene (5ml) were heated at reflux for 10 mins. After addition of methanol (10ml), the mixture was heated on a steam bath for a further 10 mins to destroy excess acid chloride. 0n evaporation of low-boiling material, the remaining liquid was diluted with toluene (100ml) and separated by chromatography on a silica gel column. Nitrobenzene eluted first, and the material eluted with a 50:50 mixture of toluene:ethyl acetate was collected. The solvent was evaporated and ethanol was added to the residue, which upon trituration afforded the product as a yellow solid.

1. temperatureat reflux for 10 mins
2. temperaturethe mixture was heated on a steam bath for a further 10 mins
3. customto destroy excess acid chloride
4. custom0n evaporation of low-boiling material
5. additionthe remaining liquid was diluted with toluene (100ml)
6. customseparated by chromatography on a silica gel column
7. washNitrobenzene eluted first
8. washthe material eluted with a 50:50 mixture of toluene
9. customethyl acetate was collected
10. customThe solvent was evaporated
11. additionethanol was added to the residue, which upon trituration