HCID 15661031, compound → HCID 15661032, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the ester from Step 1 (440 mg, 1.28 mmol) in dry toluene (5 mL) was added dropwise at room temperature a solution of N,N-dimethylamino dimethyl aluminum 0.8M in toluene (16 mL, 12.8 mmol). The resulting solution was heated to 70° C. for 2 hours. The reaction mixture was then cooled to 0° C. and quenched with excess ethyl acetate followed by addition of lN aqueous HCl. The solvents were removed under reduced pressure and the resulting solid was filtered, washed with ethyl acetate to afford the title product which was used as such for the next step.

Provenance & Evidence