HCID 19817120, compound → HCID 19817117, compound

Participants

Reaction Steps

The product of Stage (ii) (0.93 g) was dissolved in hydrochloric acid (2N, 15 ml) and the resulting solution was basified in sodium carbonate solution (2N) and extracted with ethyl acetate. The insoluble solid (title compound free base, 0.28 g) was filtered off and the combined organic extract was dried (MgSO4) and evaporated to dryness to give more title compound base as a solid (0.42 g) m.p. 198°-200°. A sample of this material (0.21 g) was dissolved in methanol (6 ml) and treated with ethereal hydrogen chloride. On diluting with ether (30 ml), the title salt was precipitated. This was triturated with ether (200 ml) and then dried at 50° in vacuo to give the title compound as a solid (0.19 g), m.p. 126°-9°. (dec).

Provenance & Evidence