HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4,5-Dimethyl-2-(4-methylphenyl)oxazole N-Oxide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Methylbenzaldehyde | HCID 7725 | — |
| Reactant | 2-Oxime 2,3-butanedione | HCID 6398969 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4,5-Dimethyl-2-(4-methylphenyl)oxazole N-Oxide Hydrochloride | HCID 19888757 | — |
Reaction Steps
At 0°-5° C., dry HCl was bubble through a solution of p-tolualdehyde (125 g, 1.04 mol) and 3-oximino-2-butanone (95.6 g, 0.946 mol) in 350 ml of ethyl acetate. Title product was precipitated by dilution with ether and recovered by filtration with ether wash, 207 g; mp 198°-200° C. (dec).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05036079 |
| Source dataset | uspto-grants-1991_07 |
| ORD ID | ord-3c565da24de3421a982e69539c0d46f8 |
| Source note | uspto-grants-1991_07 |