Ammonia → HCID 15662327, compound

HRID 1087460Notes

Reaction equation

HRID 1087460 reaction equation
C([O:4][CH2:5][C:6]([NH:8][C:9]1[S:10][C:11]2[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:12]=2[N:13]=1)=[O:7])(=O)C.N>CO>[OH:4][CH2:5][C:6]([NH:8][C:9]1[S:10][C:11]2[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:12]=2[N:13]=1)=[O:7]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 15662326HCID 15662326, compound

Product 1

HCID 15662327HCID 15662327, compoundYield 93.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(Acetoxyacetylamino)-6-methoxybenzothiazole (13.0 g) prepared in Example 2 is dissolved in methanol (1000 ml) and thereto is added 28% aqueous ammonia (100 ml) and the mixture is stirred at room temperature for 1 hour. The solvent is distilled off and the resulting solids are washed with water, dried and recrystallized from ethanol to give the title compound (10.3 g) having the following physical properties.

Workup

  1. distillationThe solvent is distilled off
  2. washthe resulting solids are washed with water
  3. customdried
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-30ff9c36434b4bba85722f54daabdc56
Source dataset
uspto-grants-1991_07
Patent number
US05036086

Reaction notes

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