Ammonia → HCID 15662331, compound

HRID 1087464Notes

Reaction equation

HRID 1087464 reaction equation
C([O:4][CH2:5][C:6]([NH:8][C:9]1[S:10][C:11]2[CH:17]=[C:16]([CH3:18])[C:15]([CH3:19])=[CH:14][C:12]=2[N:13]=1)=[O:7])(=O)C.N>CO>[CH3:19][C:15]1[C:16]([CH3:18])=[CH:17][C:11]2[S:10][C:9]([NH:8][C:6](=[O:7])[CH2:5][OH:4])=[N:13][C:12]=2[CH:14]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 15662330HCID 15662330, compound

Product 1

HCID 15662331HCID 15662331, compoundYield 89.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(Acetoxyacetylamino)-5,6-dimethylbenzothiazole (4.2 g) prepared in Example 6 is dissolved in methanol (200 ml) and thereto is added 28% aqueous ammonia (20 ml) and the mixture is stirred at room temperature for 1 hour. The solvent is distilled off and the resulting solids are washed with water, dried and recrystallized from ethanol to give the title compound (3.2 g) having the following physical properties.

Workup

  1. distillationThe solvent is distilled off
  2. washthe resulting solids are washed with water
  3. customdried
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-2ac2a157cdee40fc9e570dbd850707a2
Source dataset
uspto-grants-1991_07
Patent number
US05036086

Reaction notes

Loading…