Methoxyacetyl chloride → HCID 15662338, compound

HRID 1087475Notes

Reaction equation

HRID 1087475 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:12][O:13][CH2:14][C:15](Cl)=[O:16]>N1C=CC=CC=1>[F:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([NH:1][C:15](=[O:16])[CH2:14][O:13][CH3:12])[S:3][C:4]=2[CH:10]=1

Participants

4

Reactant 2

HCID 96623Methoxyacetyl chlorideHCID 3199542-Amino-6-fluorobenzothiazole

Product 1

HCID 15662338HCID 15662338, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-Amino-6-fluorobenzothiazole (3.3 g) is dissolved in pyridine (80 ml) and thereto is added dropwise methoxyacetyl chloride (2.0 ml) at room temperature. After the mixture is stirred at room temperature for 2 hours, the solvent is distilled off. The resulting solids are washed with water, then with diethyl ether, dried and recrystallized from ethanol to give the title compound (3.5 g) having the following physical properties.

Workup

  1. distillationthe solvent is distilled off
  2. washThe resulting solids are washed with water
  3. dry with materialwith diethyl ether, dried
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-a0c24e54ac454380ad240b93e35fe069
Source dataset
uspto-grants-1991_07
Patent number
US05036086

Reaction notes

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