Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(4-Chlorophenyl)piperazine | HCID 97478 | — |
| Reactant | 2(3-Chloropropyl)naphtho[1,8-cd]isothiazole 1,1-dioxide | HCID 14580026 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 14580036 | HCID 14580036 | 36.1% |
Reaction Steps
The experiment is carried out as in Example 1, starting with 2-(3-chloropropyl)naphtho[1,8-cd]isothiazole 1,1-dioxide (5.3 g), triethylamine (2.6 cc), 4-(4-chlorophenyl) piperazine (5 g) and sodium iodide (2.8 g) in toluene (50 cc). The mixture is heated for 6 hours at boiling point, then cooled to a temperature of about 20° C. After recrystallization, firstly from boiling acetonitrile 6 hours and secondly from boiling methyl ethyl ketone (15 cc), 2-{3-[4-(4-chlorophenyl)-1-piperazinyl ]propyl}naptho[1,8-cd]isothiazole 1,1-dioxide (3 g) is obtained, m.p. 120° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05036075 |
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| Source dataset | uspto-grants-1991_07 |
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| ORD ID | ord-4b40a5315820467f8a71aa51acbe6f20 |
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| Source note | uspto-grants-1991_07 |
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